Preheat the oven to 350 degrees F (175 degrees C). Grease an 8½ x 4½-inch loaf pan.
In a medium bowl, whisk together the flour, baking soda, spice, baking powder and salt.
In the large bowl, add the eggs, sugars and vanilla. Beat with a hand mixer or a stand mixer on medium/high speed until well combined. Add the pumpkin and butter mixing on low speed and slowly add the dry ingredients until well blended and the batter is smooth.
Pour the batter into the prepared loaf pan and sprinkle with the pumpkin seeds.
Transfer to the oven and bake for approximately 55-60 minutes or until a toothpick inserted into the center of the bread comes out clean.
Allow the bread to cool in the pan for 30 minutes then invert onto a wire rack to cool completely.
Slice into 1 inch thick slices and serve warm or room temperature.