Season your chuck roast with salt and pepper on both sides.
Heat the oil in the instant pot. When shimmering, add the roast to the pot.
Cook the roast until seared and deeply browned, approximately 3-5 minutes. Turn the roast onto another side for 3-4 minutes, repeating until all sides are browned.
Turn the instant pot to "Pressure Cook" on high and set to 50 minutes.
Add potatoes, onions, mushrooms and carrots to pot.
Whisk together the wine, beef broth, Worcestershire sauce, garlic powder, onion powder, smoked paprika and Italian seasoning. Pour the liquid over the roast and potatoes.
Place lid on the pot and turn to locked position. Set the vent to the sealed position.
When done cooking, allow the pressure to release naturally for 10 minutes.
After 10 minutes, turn vent to the venting release position and allow all of the steam to release.
Transfer the roast, potatoes, onions, and carrots to a platter and keep warm.
Stir together the butter and corn starch until smooth.
Whisk the butter mixture into the broth and stir until slightly thickened..